Article
EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Aug 2005
Bhargava Rohit, Gerald William L, Li Allan R, Pan Qiulu, Lal Priti, Ladanyi Marc, Chen Beiyun
Abstract excerpt
The human epidermal growth factor receptor (HER) family of receptor tyrosine kinase has been extensively studied in breast cancer; however, systematic studies of EGFR gene amplification and protein overexpression in breast carcinoma are lacking. We studied EGFR gene amplification by chromogenic in situ hybridization (CISH) and protein expression by immunohistochemistry in 175 breast carcinomas, using tissue...
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