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EGF-r gene copy number changes in renal cell carcinoma detected by fluorescencein situ hybridization

1 Apr 1998

Abstract excerpt

Expression of epidermal growth factor receptor (EGF-r) is a frequent event in renal cell carcinoma (RCC). To investigate the role of EGF-r gene copy number changes related to EGF-r overexpression, 50 RCC specimens were examined by fluorescence in situ hybridization (FISH) and immunohistochemistry. Dual-labelling FISH with a repetitive pericentromeric probe for chromosome 7 and a probe for the EGF-r gene (at 7p13)...

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PMID: 9664910
DOI: 10.1002/(sici)1096-9896(199804)184:4<424::aid-path1223>3.0.co;2-a

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