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Article

Multifaceted dysregulation of the epidermal growth factor receptor pathway in clear cell sarcoma of the kidney.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2007

Little Suzanne E, Bax Dorine A, Rodriguez-Pinilla Maria, Natrajan Rachael, Messahel Boo, Pritchard-Jones Kathy, Vujanic Gordan M, Reis-Filho Jorge S, Jones Chris

Abstract excerpt

PURPOSE: Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase overexpressed in a variety of human malignancies, against which targeted therapies have shown efficacy in lung and brain tumors. Clinical responses to EGFR inhibitors have been found to be highly dependent on the presence of activating mutations, whereas gene amplification, downstream activation of Akt, and abnormalities in PTEN are...

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Share to Gene Amplification
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17646270
DOI: 10.1158/1078-0432.CCR-07-0398

Genes

EGFR
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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