Ha-ras induction of the invasive phenotype results in up-regulation of epidermal growth factor receptors and altered responsiveness to epidermal growth factor in human papillary transitional cell carcinoma cells.

Abstract excerpt

Recent studies have shown that orthotopic (transurethral) transplantation of human bladder cancer cell lines into nude mice permits tumor growth that more accurately reflects their clinical malignant status in the original host. We have previously demonstrated that transfection and overexpression of normal or mutated c-Ha-ras genes into a noninvasive human papillary transitional cell carcinoma cell line confer...

Topics

• Blotting, Northern
• Carcinoma, Transitional Cell
• Cell Division
• Cell Line
• Epidermal Growth Factor
• ErbB Receptors
• Genes, ras
• Humans
• Neoplasm Invasiveness
• Phenotype