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Article

Concomitant overexpression of theEGFR anderbB-2 genes in renal cell carcinoma (RCC) is correlated with dedifferentiation and metastasis

20 Feb 1996

Abstract excerpt

Gene amplification or structural alteration of different erbB genes exerts a transforming effect in a variety of human neoplasms. Overexpression of the EGF receptor is associated with tumor initiation and progression of renal cell carcinoma (RCC). However, the role of erbB-2 in these processes remains unknown. We investigated 34 renal cell carcinomas for gene amplification and expression of the EGFR and erbB-2...

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PMID: 8600053
DOI: 10.1002/(sici)1097-0215(19960220)69:1<17::aid-ijc4>3.0.co;2-z

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