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Article

Rapid testing of gene-gene interactions in genome-wide association studies of binary and quantitative phenotypes.

Genetic epidemiology - 1 Dec 2011

Bhattacharya Kanishka, McCarthy Mark I, Morris Andrew P

Abstract excerpt

Genome-wide association (GWA) studies have been extremely successful in identifying novel loci contributing effects to a wide range of complex human traits. However, despite this success, the joint marginal effects of these loci account for only a small proportion of the heritability of these traits. Interactions between variants in different loci are not typically modelled in traditional GWA analysis, but may...

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Identifiers

PMID: 21948692
DOI: 10.1002/gepi.20629
PMCID: PMC3410530

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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