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Dissecting graft‐versus‐leukemia from graft‐versus‐host‐disease using novel strategies

20 Mar 2013

Abstract excerpt

The intrinsic anti-leukemic effect of allogeneic hematopoietic cell transplantation (HCT) is dependent on genetic disparity between donor and recipient, intimately associated with graft-versus-host disease (GVHD), and mediated by lymphocytes contained in or derived from the donor hematopoietic cell graft. Three decades of intense effort have not identified clinical strategies that can reliably separate the...

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PMID: 23510414
DOI: 10.1111/tan.12090

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