Article

Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation

2023-04-05

Abstract excerpt

Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia, whereby donor T- effector cells recognize leukemia neoantigens. However, a substantial fraction of patients experience relapses because of the failure of the immunological responses to control leukemic outgrowth. Here, through a broad immunogene...

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Literature Corpus work: 3f08b380-6aca-5dac-a1d8-556c4094ebbf
DOI: 10.21203/rs.3.rs-2773498/v1

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