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Article

Haploidentical hematopoietic transplantation for the cure of leukemia: from its biology to clinical translation

4 Oct 2016

Abstract excerpt

The present review describes the biology of human leukocyte antigen haplotype mismatched ("haploidentical") transplantation, its translation to clinical practice to cure leukemia, and the results of current transplantation protocols. The 1990s saw what had been major drawbacks of haploidentical transplantation, ie, very strong host-versus-graft and graft-versus-host alloresponses, which led respectively to...

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PMID: 27697774
DOI: 10.1182/blood-2016-07-730564

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