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Leukemia relapse via genetic immune escape after allogeneic hematopoietic cell transplantation

31 May 2023

Abstract excerpt

Graft-versus-leukemia (GvL) reactions are responsible for the effectiveness of allogeneic hematopoietic cell transplantation as a treatment modality for myeloid neoplasia, whereby donor T- effector cells recognize leukemia neoantigens. However, a substantial fraction of patients experiences relapses because of the failure of the immunological responses to control leukemic outgrowth. Here, through a broad...

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PMID: 37258544
DOI: 10.1038/s41467-023-38113-4

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