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Article

In the absence of reactive oxygen species, T cells default to a Th1 phenotype and mediate protection against pulmonary Cryptococcus neoformans infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2006

Snelgrove Robert J, Edwards Lorna, Williams Andrew E, Rae Aaron J, Hussell Tracy

Abstract excerpt

In recent years, the prevalence of invasive fungal infections has increased, attributed mostly to the rising population of immunocompromised individuals. Cryptococcus neoformans has been one of the most devastating, with an estimated 6-8% of AIDS-infected patients succumbing to Cryptococcus-associated meningitis. Reactive oxygen species (ROS) are potent antimicrobial agents but also play a significant role in...

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Identifiers

PMID: 17015737
DOI: 10.4049/jimmunol.177.8.5509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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