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Article

Role of NADPH Oxidase versus Neutrophil Proteases in Antimicrobial Host Defense

7 Dec 2011

Abstract excerpt

NADPH oxidase is a crucial enzyme in mediating antimicrobial host defense and in regulating inflammation. Patients with chronic granulomatous disease, an inherited disorder of NADPH oxidase in which phagocytes are defective in generation of reactive oxidant intermediates (ROIs), suffer from life-threatening bacterial and fungal infections. The mechanisms by which NADPH oxidase mediate host defense are unclear. In...

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Share to Antifungal resistance and susceptibility
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PMID: 22163282
DOI: 10.1371/journal.pone.0028149

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