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Cellular Effects of Curcumin on Plasmodium falciparum Include Disruption of Microtubules

7 Mar 2013

Abstract excerpt

Curcumin has been widely investigated for its myriad cellular effects resulting in reduced proliferation of various eukaryotic cells including cancer cells and the human malaria parasite Plasmodium falciparum. Studies with human cancer cell lines HT-29, Caco-2, and MCF-7 suggest that curcumin can bind to tubulin and induce alterations in microtubule structure. Based on this finding, we investigated whether...

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PMID: 23505424
DOI: 10.1371/journal.pone.0057302

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