Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced stability of microtubules contributes in the development of colchicine resistance in MCF-7 cells.

Biochemical pharmacology - 15 May 2017

Rai Ankit, Kapoor Sonia, Naaz Afsana, Kumar Santra Manas, Panda Dulal

Abstract excerpt

Understanding the mechanism of resistance to tubulin-targeted anticancer drugs is important for improved chemotherapy. In this work, a colchicine-resistant MCF-7 cell line (MCF-7Col30) was generated by the gradual increment of colchicine treatment and the MCF-7Col30 showed ∼8-fold resistance towards colchicine. MCF-7Col30 cells showed ∼2.5-fold resistance against microtubule depolymerizing agents, vinblastine,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Colchicine
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glutamic Acid

Share to MCF-7 Cells

Share to Microtubules

Share to Paclitaxel

Share to Tubulin

Source

Identifiers

PMID: 28242250
DOI: 10.1016/j.bcp.2017.02.018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced stability of microtubules contributes in the development of colchicine resistance in MCF-7 cells.PMID 28242250Read ↗

A review of research progress of antitumor drugs based on tubulin targetsSemantic proximity Read ↗

Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistanceSemantic proximity Read ↗

Microtubules and Cell Division: Potential Pharmacological Targets in Cancer TherapySemantic proximity Read ↗

The Elephant in the Room: The Role of Microtubules in Cancer.Semantic proximity Read ↗

Cancer cells acquire mitotic drug resistance properties through beta I-tubulin mutations and alterations in the expression of beta-tubulin isotypes.Semantic proximity Read ↗

The Tubulin Code and Tubulin-Modifying Enzymes in Autophagy and CancerSemantic proximity Read ↗

Mutations in alpha- and beta-tubulin that stabilize microtubules and confer resistance to colcemid and vinblastine.Semantic proximity Read ↗

Multiple mechanisms underlying acquired resistance to taxanes in selected docetaxel-resistant MCF-7 breast cancer cellsSemantic proximity Read ↗

KIF2C promotes paclitaxel resistance by depolymerizing polyglutamylated microtubulesSemantic proximity Read ↗

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.Semantic proximity Read ↗

Microtubules: A dynamic target in cancer therapySemantic proximity Read ↗

Microtubule Targeting Agents as Cancer Chemotherapeutics: An Overview of Molecular Hybrids as Stabilizing and Destabilizing AgentsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.