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Antileishmanial activity and tubulin polymerization inhibition of podophyllotoxin derivatives on Leishmania infantum

28 Jun 2017

Abstract excerpt

Leishmania microtubules play an important role not only in cell division, but also in keeping the shape of the parasite and motility of its free-living stages. Microtubules result from the self-assembly of alpha and beta tubulins, two phylogenetically conserved and very abundant eukaryotic proteins in kinetoplastids. The colchicine binding domain has inspired the discovery and development of several drugs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 28719882
DOI: 10.1016/j.ijpddr.2017.06.003

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