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Article

Paradoxical relationship between acetylator phenotype and amonafide toxicity.

Clinical pharmacology and therapeutics - 1 Nov 1991

Ratain M J, Mick R, Berezin F, Janisch L, Schilsky R L, Williams S F, Smiddy J

Abstract excerpt

Patients receiving the investigational antineoplastic agent amonafide underwent prospective determination of acetylator phenotype with use of caffeine as a test drug. Fast acetylators of caffeine had significantly greater toxicity (myelosuppression) after amonafide treatment than slow acetylators, presumably because of greater conversion of amonafide to the active acetylated metabolite. Furthermore, the estimated...

Topics

Acetylation
Adenine
Antineoplastic Agents
Body Weight
Female
Humans
Imides
Isoquinolines
Leukopenia
Male
Middle Aged
Naphthalimides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Organophosphonates

Phenotype

Prospective Studies

Source

Identifiers

PMID: 1934870
DOI: 10.1038/clpt.1991.183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1934870-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Paradoxical relationship between acetylator phenotype and amonafide toxicity.PMID 1934870Read ↗

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