Article
Naturally occurring dominant drug resistance mutations occur infrequently in the setting of recently acquired hepatitis C.
Antiviral therapy - 1 Jan 2015
Applegate Tanya L, Gaudieri Silvana, Plauzolles Anne, Chopra Abha, Grebely Jason, Lucas Michaela, Hellard Margaret, Luciani Fabio, Dore Gregory J, Matthews Gail V
Abstract excerpt
BACKGROUND: Direct-acting antivirals (DAAs) are predicted to transform hepatitis C therapy, yet little is known about the prevalence of naturally occurring resistance mutations in recently acquired HCV. This study aimed to determine the prevalence and frequency of drug resistance mutations in the viral quasispecies among HIV-positive and -negative individuals with recent HCV. METHODS: The NS3 protease, NS5A and...
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