Article

Selection-guided discovery in South Asians implicates the MAPT locus in insulin resistance

2026-03-13

Abstract excerpt

South Asians constitute 25% of the global population yet account for 33% of individuals living with type 2 diabetes (T2D) (1). Despite this burden, they remain substantially underrepresented in genome-wide association studies (GWAS), limiting discovery of ancestry-relevant disease biology (2). This limits biological insight and hampers genomic discovery. Here we integrated genome-wide signatures of recent positive...

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Literature Corpus work: 44f5b717-d577-5eec-8240-1887dc72c329
DOI: 10.64898/2026.03.12.26348237

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