Article
Genome-wide association scans identified CTNNBL1 as a novel gene for obesity.
Human molecular genetics - 15 Jun 2008
Liu Yong-Jun, Liu Xiao-Gang, Wang Liang, Dina Christian, Yan Han, Liu Jian-Feng, Levy Shawn, Papasian Christopher J, Drees Betty M, Hamilton James J, Meyre David, Delplanque Jerome, Pei Yu-Fang, Zhang Lei, Recker Robert R, Froguel Philippe, Deng Hong-Wen
Abstract excerpt
Obesity is a major public health problem with strong genetic determination; however, the genetic factors underlying obesity are largely unknown. In this study, we performed a genome-wide association scan for obesity by examining approximately 500 000 single-nucleotide polymorphisms (SNPs) in a sample of 1000 unrelated US Caucasians. We identified a novel gene, CTNNBL1, which has multiple SNPs associated with body...
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