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Article

LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice.

The Journal of biological chemistry - 26 Apr 2013

Chen Juan, Fu Rui, Cui Yan, Li Yu-shan, Pan Ji-rong, Liu Jia-li, Luo Hao-shu, Yin Jing-dong, Li De-fa, Cui Sheng

Abstract excerpt

In addition to the well known regulating effects of leptin on energy balance and glucose homeostasis through the central nervous system, circulating leptin has a direct effect on pancreatic islet and insulin secretion through its receptor (OBRb). The LIM-homeodomain transcription factor Isl-1 is expressed in all classes of pancreatic endocrine cells and is involved in regulating both islet development and insulin...

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Source

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Identifiers

PMID: 23504315
DOI: 10.1074/jbc.M113.450536
PMCID: PMC3636923

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice.PMID 23504315Read ↗

Islet Cell and Extrapancreatic Expression of the LIM Domain Homeobox Geneisl-1Semantic proximity Read ↗

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthoodSemantic proximity Read ↗

The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.Semantic proximity Read ↗

Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis.Semantic proximity Read ↗

Leptin Signaling in the Central Nervous System and the PeripherySemantic proximity Read ↗

ISL-1 is overexpressed in non-Hodgkin lymphoma and promotes lymphoma cell proliferation by forming a p-STAT3/p-c-Jun/ISL-1 complexSemantic proximity Read ↗

Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes.Semantic proximity Read ↗

The homeodomain LIM protein Isl-1 is expressed in subsets of neurons and endocrine cells in the adult rat.Semantic proximity Read ↗

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Drosophila adiponectin receptor in insulin producing cells regulates glucose and lipid metabolism by controlling insulin secretion.Semantic proximity Read ↗

DLL1- and DLL4-Mediated Notch Signaling Is Essential for Adult Pancreatic Islet HomeostasisSemantic proximity Read ↗

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