Article
Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes.
Diabetes - 1 May 2002
Barat-Houari Mouna, Clément Karine, Vatin Vincent, Dina Christian, Bonhomme Geneviève, Vasseur Francis, Guy-Grand Bernard, Froguel Philippe
Abstract excerpt
The Lim domain homeobox gene (Isl-1) is a positional candidate gene for obesity that maps on chromosome 5q11-q13, a locus linked to BMI and leptin levels in French Caucasians. Isl-1 might be involved in body weight regulation and glucose homeostasis via the activation of proglucagon gene expression, which encodes for glucagon and glucagon-like peptides. By mutation screening of 72 obese subjects, we identified...
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