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Article

STAT3 signalling is required for leptin regulation of energy balance but not reproduction.

Nature - 20 Feb 2003

Bates Sarah H, Stearns Walter H, Dundon Trevor A, Schubert Markus, Tso Annette W K, Wang Yongping, Banks Alexander S, Lavery Hugh J, Haq Asma K, Maratos-Flier Eleftheria, Neel Benjamin G, Schwartz Michael W, Myers Martin G

Abstract excerpt

Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb). LRb regulates energy homeostasis and neuroendocrine function; the absence of LRb in db/db mice results in obesity, impaired growth, infertility and diabetes. Tyr 113...

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Source

Identifiers

PMID: 12594516
DOI: 10.1038/nature01388

Genes

STAT3
NPY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12594516-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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