Article
STAT3 signalling is required for leptin regulation of energy balance but not reproduction.
Nature - 20 Feb 2003
Bates Sarah H, Stearns Walter H, Dundon Trevor A, Schubert Markus, Tso Annette W K, Wang Yongping, Banks Alexander S, Lavery Hugh J, Haq Asma K, Maratos-Flier Eleftheria, Neel Benjamin G, Schwartz Michael W, Myers Martin G
Abstract excerpt
Secretion of leptin from adipocytes communicates body energy status to the brain by activating the leptin receptor long form (LRb). LRb regulates energy homeostasis and neuroendocrine function; the absence of LRb in db/db mice results in obesity, impaired growth, infertility and diabetes. Tyr 1138 of LRb mediates activation of the transcription factor STAT3 during leptin action. To investigate the contribution of...
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