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Article

Transcriptional and physiological roles for STAT proteins in leptin action

27 Jan 2019

Abstract excerpt

Objectives Leptin acts via its receptor LepRb on specialized neurons in the brain to modulate food intake, energy expenditure, and body weight. LepRb activates signal transducers and activators of transcription (STATs, including STAT1, STAT3, and STAT5) to control gene expression. Methods Because STAT3 is crucial for physiologic leptin action, we used TRAP-seq to examine gene expression in LepRb neurons of mice...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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Identifiers

PMID: 30718218
DOI: 10.1016/j.molmet.2019.01.007

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