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Article

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.

Molecular neurobiology - 1 Jun 2018

Brasil Aline A, Magalhães Rayne S S, De Carvalho Mariana D C, Paiva Isabel, Gerhardt Ellen, Pereira Marcos D, Outeiro Tiago F, Eleutherio Elis C A

Abstract excerpt

Among the familial forms of amyotrophic lateral sclerosis (fALS), 20% are associated with the Cu,Zn-superoxide dismutase (Sod1). fALS is characterized by the accumulation of aggregated proteins and the increase in oxidative stress markers. Here, we used the non-invasive bimolecular fluorescence complementation (BiFC) assay in human H4 cells to investigate the kinetics of aggregation and subcellular localization...

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Identifiers

PMID: 28884318
DOI: 10.1007/s12035-017-0755-4
PMCID: PMC5948255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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