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Article

ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging.

Redox biology - 1 Feb 2024

Guo Ying, Guan Teng, Yu Qiang, Sanghai Nitesh, Shafiq Kashfia, Li Meiyu, Jiao Xin, Na Donghui, Zhang Guohui, Kong Jiming

Abstract excerpt

Oxidative stress (OS) is regarded as the dominant theory for aging. While compelling correlative data have been generated to support the OS theory, a direct cause-and-effect relationship between the accumulation of oxidation-mediated damage and aging has not been firmly established. Superoxide dismutase 1 (SOD1) is a primary antioxidant in all cells. It is, however, susceptible to oxidation due to OS and gains...

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Identifiers

PMID: 38056310
DOI: 10.1016/j.redox.2023.102972
PMCID: PMC10746562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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