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Article

A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism.

PloS one - 4 Jun 2008

Ratnaparkhi Anuradha, Lawless George M, Schweizer Felix E, Golshani Peyman, Jackson George R

Abstract excerpt

ALS8 is caused by a dominant mutation in an evolutionarily conserved protein, VAPB (vesicle-associated membrane protein (VAMP)-associated membrane protein B)/ALS8). We have established a fly model of ALS8 using the corresponding mutation in Drosophila VAPB (dVAP33A) and examined the effects of this mutation on VAP function using genetic and morphological analyses. By simultaneously assessing the effects of...

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Identifiers

PMID: 18523548
DOI: 10.1371/journal.pone.0002334
PMCID: PMC2390852

Genes

VAPB

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A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism.PMID 18523548Read ↗

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