Glutathione S-transferase polymorphisms: influence on susceptibility to cancer.

doi:10.1016/s0009-2797(97)00172-5

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Article

Glutathione S-transferase polymorphisms: influence on susceptibility to cancer.

Chemico-biological interactions - 24 Apr 1998

Strange R C, Lear J T, Fryer A A

Abstract excerpt

The glutathione S-transferase supergene family includes several loci that demonstrate well characterised polymorphisms. The apparently critical role of these enzymes in cellular protection from the cytotoxic and mutagenic effects of electrophiles suggest that alleles associated with impaired deto...

Topics

Alleles
Carcinoma, Basal Cell
Female
Genotype
Glutathione Transferase
Humans
Inactivation, Metabolic
Male
Mutation
Neoplasms
Polymorphism, Genetic
Risk Factors
Skin Neoplasms
Time Factors

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