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Article

Response to azathioprine treatment in autoimmune hepatitis is dependent on glutathione transferase genotypes.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver - 1 Apr 2025

Appell Malin Lindqvist, Hindorf Ulf, Almer Sven, Haglund Sofie

Abstract excerpt

BACKGROUND: Azathioprine (AZA) is part of the standard treatment for autoimmune hepatitis (AIH). The first step in the complex bioconversion of AZA to active metabolites is mediated by glutathione transferases (GSTs). AIMS: Elucidate the association between GSTM1 and GSTT1 copy number variation (CNV), genetic variation in GSTA2, GSTP1, and inosine-triphosphate-pyrophosphatase, and the response to AZA in AIH....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39863504
DOI: 10.1016/j.dld.2024.12.026

Genes

GSTM1
GSTT1
GSTA2
GSTP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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Response to azathioprine treatment in autoimmune hepatitis is dependent on glutathione transferase genotypes.PMID 39863504Read ↗

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