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Article

Dynamic nuclear polarization study of inhibitor binding to the M2(18-60) proton transporter from influenza A.

Biochemistry - 23 Apr 2013

Andreas Loren B, Barnes Alexander B, Corzilius Björn, Chou James J, Miller Eric A, Caporini Marc, Rosay Melanie, Griffin Robert G

Abstract excerpt

We demonstrate the use of dynamic nuclear polarization (DNP) to elucidate ligand binding to a membrane protein using dipolar recoupling magic angle spinning (MAS) NMR. In particular, we detect drug binding in the proton transporter M2(18-60) from influenza A using recoupling experiments at room temperature and with cryogenic DNP. The results indicate that the pore binding site of rimantadine is correlated with...

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Identifiers

PMID: 23480101
DOI: 10.1021/bi400150x
PMCID: PMC3646523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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