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Article

Coexistence of two adamantane binding sites in the influenza A M2 ion channel.

Proceedings of the National Academy of Sciences of the United States of America - 3 Aug 2010

Rosenberg Matthew R, Casarotto Marco G

Abstract excerpt

The influenza A virus contains a proton-selective ion channel (M2) that is the target of the adamantane family of drug inhibitors. Two recently published studies relating to adamantane binding of the M2 ion channel using X-ray crystallography and solution NMR have reignited interest in the potential use of adamantanes in combating the spread of influenza A. However, these two studies propose different binding...

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PMID: 20643947
DOI: 10.1073/pnas.1002051107
PMCID: PMC2922235

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SPR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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