Article
Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2013
Berlau Daniel J, Corrada María M, Robinson John L, Geser Felix, Arnold Steven E, Lee Virginia M-Y, Kawas Claudia H, Trojanowski John Q
Abstract excerpt
OBJECTIVE: Apolipoprotein E (APOE) ε2 carriers may be protected from dementia because of reduced levels of cortical β-amyloid. In the oldest-old, however, APOE ε2 carriers have high β-amyloid plaque scores and preserved cognition. We compared different measures of β-amyloid pathology across APOE genotypes in the oldest-old, and their relationship with dementia. METHODS: The study included 96 participants from The...
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