Article
Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium.
Molecular pharmacology - 1 Oct 1998
Strassburg C P, Nguyen N, Manns M P, Tukey R H
Abstract excerpt
The human UDP-glucuronosyltransferase (UGT) 1A (UGT1A) locus is regulated in a tissue specific fashion in liver and extrahepatic tissues. Three extrahepatic UGT1A proteins, UGT1A7, UGT1A8, and UGT1A10, have been discovered and are believed to contribute to the diversity of extrahepatic glucuronidation. UGTs eliminate by glucuronidation a broad variety of endobiotic and xenobiotic substrates, which include...
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