Article
[Review on gene polymorphisms of UDP-glucuronosyltransferases and genetic susceptibility of cancer].
Wei sheng yan jiu = Journal of hygiene research - 1 Sept 2008
Wang Yadong, Zheng Yuxin
Abstract excerpt
UDP-glucuronosyltransferases (UGT) are important phase II metabolizing enzymes that catalyse the glucuronidation of numerous endobiotics and xenobiotics. Several human hepatic and extrahepatic UGT isozymes have been characterized with respect to their substrate specificity, tissue expression and gene structure. Genetic polymorphisms have been identified for almost all the UGT family members. Some Polymorphisms of...
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