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Article

CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.

The Journal of biological chemistry - 15 Jun 2012

Wang Hailong, Shao Zhengping, Shi Linda Z, Hwang Patty Yi-Hwa, Truong Lan N, Berns Michael W, Chen David J, Wu Xiaohua

Abstract excerpt

CtIP (CtBP-interacting protein) associates with BRCA1 and the Mre11-Rad50-Nbs1 (MRN) complex and plays an essential role in homologous recombination (HR)-mediated DNA double-stranded break (DSB) repair. It has been described that CtIP forms dimers in mammalian cells, but the biological significan...

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Share to Amino Acid Motifs
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human

Share to DNA Breaks, Double-Stranded

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Source

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Identifiers

PMID: 22544744
DOI: 10.1074/jbc.M112.355354
PMCID: PMC3375568

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22544744-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

CtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.PMID 22544744Read ↗

The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break RepairSemantic proximity Read ↗

Structural and biophysical analysis of human DNA repair protein CtIPSemantic proximity Read ↗

CtIP-mediated resection is essential for viability and can operate independently of BRCA1.Semantic proximity Read ↗

Human CtIP: A ‘double agent’ in DNA repair and tumorigenesisSemantic proximity Read ↗

DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.Semantic proximity Read ↗

Structural basis for the coiled-coil architecture of human CtIP.Semantic proximity Read ↗

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain.Semantic proximity Read ↗

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repairSemantic proximity Read ↗

The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediatorSemantic proximity Read ↗

ATM antagonizes NHEJ proteins assembly and DNA-ends synapsis at single-ended DNA double strand breaksSemantic proximity Read ↗

Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaksSemantic proximity Read ↗

The DNA resection protein CtIP promotes mammary tumorigenesis.Semantic proximity Read ↗

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