Article
DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.
Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2021
Wang Xiaobin S, Menolfi Demis, Wu-Baer Foon, Fangazio Marco, Meyer Stefanie N, Shao Zhengping, Wang Yunyue, Zhu Yimeng, Lee Brian J, Estes Verna M, Cupo Olivia M, Gautier Jean, Pasqualucci Laura, Dalla-Favera Riccardo, Baer Richard, Zha Shan
Abstract excerpt
CtIP is a DNA end resection factor widely implicated in alternative end-joining (A-EJ)-mediated translocations in cell-based reporter systems. To address the physiological role of CtIP, an essential gene, in translocation-mediated lymphomagenesis, we introduced the T855A mutation at murine CtIP to nonhomologous end-joining and Tp53 double-deficient mice that routinely succumbed to lymphomas carrying A-EJ-mediated...
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