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Article

HIV-1 conserved-element vaccines: relationship between sequence conservation and replicative capacity.

Journal of virology - 1 May 2013

Rolland Morgane, Manocheewa Siriphan, Swain J Victor, Lanxon-Cookson Erinn C, Kim Moon, Westfall Dylan H, Larsen Brendan B, Gilbert Peter B, Mullins James I

Abstract excerpt

To overcome the problem of HIV-1 variability, candidate vaccine antigens have been designed to be composed of conserved elements of the HIV-1 proteome. Such candidate vaccines could be improved with a better understanding of both HIV-1 evolutionary constraints and the fitness cost of specific mut...

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Share to AIDS Vaccines
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23468488
DOI: 10.1128/JVI.03033-12
PMCID: PMC3648173

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23468488-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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