Article
Candidate vaccine sequences to represent intra- and inter-clade HIV-1 variation.
PloS one - 8 Oct 2009
Yang Otto O
Abstract excerpt
A likely key factor in the failure of a HIV-1 vaccine based on cytotoxic T lymphocytes (CTL) is the natural immunodominance of epitopes that fall in variable regions of the proteome, which both increases the chance of epitope sequence mismatch with the incoming challenge strain and replicates the pathogenesis of early CTL failure due to epitope escape mutation during natural infection. To identify potential...
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