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Article

Impact of mutations in highly conserved amino acids of the HIV-1 Gag-p24 and Env-gp120 proteins on viral replication in different genetic backgrounds.

PloS one - 1 Jan 2014

Liu Yi, Rao Ushnal, McClure Jan, Konopa Philip, Manocheewa Siriphan, Kim Moon, Chen Lennie, Troyer Ryan M, Tebit Denis M, Holte Sarah, Arts Eric J, Mullins James I

Abstract excerpt

It has been hypothesized that a single mutation at a highly conserved amino acid site (HCS) can be severely deleterious to HIV in most if not all isolate-specific genetic backgrounds. Consequently, potentially universal HIV-1 vaccines exclusively targeting highly conserved regions of the viral pr...

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Share to Amino Acid Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24713822
DOI: 10.1371/journal.pone.0094240
PMCID: PMC3979772

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24713822-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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