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Article

Viral fitness implications of variation within an immunodominant CD8+ T-cell epitope of HIV-1.

Virology - 25 May 2009

Christie N M, Willer D O, Lobritz M A, Chan J K, Arts E J, Ostrowski M A, Cochrane A, Luscher M A, MacDonald K S

Abstract excerpt

Cytotoxic T-lymphocyte (CTL) epitopes within the HIV genome are subject to negative and positive selective pressures, the balance of which influences CTL escape at a given epitope. We investigated whether viral fitness requirements dictate conservation of the HLA-A2 restricted immunodominant epitope SLYNTVATL (SL9). Viral clones incorporating changes throughout the SL9 epitope region were compared to consensus...

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Share to Biological Evolution
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19368950
DOI: 10.1016/j.virol.2009.03.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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