Article
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function.
Nature - 30 Oct 2014
Viale Andrea, Pettazzoni Piergiorgio, Lyssiotis Costas A, Ying Haoqiang, Sánchez Nora, Marchesini Matteo, Carugo Alessandro, Green Tessa, Seth Sahil, Giuliani Virginia, Kost-Alimova Maria, Muller Florian, Colla Simona, Nezi Luigi, Genovese Giannicola, Deem Angela K, Kapoor Avnish, Yao Wantong, Brunetto Emanuela, Kang Ya'an, Yuan Min, Asara John M, Wang Y Alan, Heffernan Timothy P, Kimmelman Alec C, Wang Huamin, Fleming Jason B, Cantley Lewis C, DePinho Ronald A, Draetta Giulio F
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in western countries, with a median survival of 6 months and an extremely low percentage of long-term surviving patients. KRAS mutations are known to be a driver event of PDAC, but targeting mutant KRAS has proved challenging. Targeting oncogene-driven signalling pathways is a clinically validated approach for several devastating diseases....
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