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Article

Autocrine IGF1 Signaling Mediates Pancreatic Tumor Cell Dormancy in the Absence of Oncogenic Drivers.

Cell reports - 28 Feb 2017

Rajbhandari Nirakar, Lin Wan-Chi, Wehde Barbara L, Triplett Aleata A, Wagner Kay-Uwe

Abstract excerpt

Mutant KRAS and c-MYC are oncogenic drivers and rational therapeutic targets for the treatment of pancreatic cancer. Although tumor growth and homeostasis are largely dependent on these oncogenes, a few residual cancer cells are able to survive the ablation of mutant KRAS and c-MYC. By performing a genome-wide gene expression analysis of in vivo-derived bulk tumor cells and residual cancer cells lacking the...

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Source

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Identifiers

PMID: 28249168
DOI: 10.1016/j.celrep.2017.02.013
PMCID: PMC5369772

Genes

KRAS
MYC
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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