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Article

Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype.

Molecular oncology - 1 Jan 2020

Brash Douglas E, Seidman Michael M

Abstract excerpt

In this issue, the Gabrielli laboratory and collaborators address the bulky CPD lesions created in DNA when UV joins two adjacent pyrimidines (thymine or cytosine), leading to skin cancers such as melanoma (Pavey S et al. (2019) Mol Oncol). Our understanding of postreplication repair mechanisms for bulky lesions has lagged, and the newly reported predominance of translational control in the UV response has...

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Identifiers

PMID: 31821728
DOI: 10.1002/1878-0261.12612
PMCID: PMC6944110

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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