Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic nevi

19 May 2007

Abstract excerpt

The retinoblastoma (RB)/p16(INK4a) pathway regulates senescence of human melanocytes in culture and oncogene-induced senescence of melanocytic nevi in vivo. This senescence response is likely due to chromatin modifications because RB complexes from senescent melanocytes contain increased levels of histone deacetylase (HDAC) activity and tethered HDAC1. Here we show that HDAC1 is prominently detected in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to melanin and skin pigmentation
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17578512
DOI: 10.1111/j.1474-9726.2007.00308.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic assembly of chromatin complexes during cellular senescence: implications for the growth arrest of human melanocytic neviPMID 17578512Read ↗

Molecular Regulation of Melanocyte SenescenceSemantic proximity Read ↗

Lysosome-mediated processing of chromatin in senescenceSemantic proximity Read ↗

Melanomagenesis: Overcoming the barrier of melanocyte senescenceSemantic proximity Read ↗

H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescenceSemantic proximity Read ↗

Senescence-Like Phenotypes in Human Nevi.Semantic proximity Read ↗

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?Semantic proximity Read ↗

EZH2-Dependent Suppression of a Cellular Senescence Phenotype in Melanoma Cells by Inhibition of p21/ <i>CDKN1A</i> ExpressionSemantic proximity Read ↗

FBH1 protects melanocytes from transformation and is deregulated in melanomas.Semantic proximity Read ↗

BRN2 suppresses stress-induced hair greyingSemantic proximity Read ↗

HDAC1/2 Control Proliferation and Survival in Adult Epidermis and Pre‒Basal Cell Carcinoma through p16 and p53Semantic proximity Read ↗

BRAF <sup>V600E</sup> induces reversible mitotic arrest in human melanocytes via microRNA-mediated suppression of AURKBSemantic proximity Read ↗

Developmental-stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.