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Article

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions.

Nature - 14 Apr 2005

Gorgoulis Vassilis G, Vassiliou Leandros-Vassilios F, Karakaidos Panagiotis, Zacharatos Panayotis, Kotsinas Athanassios, Liloglou Triantafillos, Venere Monica, Ditullio Richard A, Kastrinakis Nikolaos G, Levy Brynn, Kletsas Dimitris, Yoneta Akihiro, Herlyn Meenhard, Kittas Christos, Halazonetis Thanos D

Abstract excerpt

DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their inactivation remains elusive. We analysed a panel of human lung hyperplasias, all of which retained wild-type p53 genes and had no signs of gross chromosomal instability, and fou...

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Identifiers

PMID: 15829965
DOI: 10.1038/nature03485

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-15829965-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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