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Article

Structure prediction and validation of the ERK8 kinase domain.

PloS one - 1 Jan 2013

Strambi Angela, Mori Mattia, Rossi Matteo, Colecchia David, Manetti Fabrizio, Carlomagno Francesca, Botta Maurizio, Chiariello Mario

Abstract excerpt

Extracellular signal-regulated kinase 8 (ERK8) has been already implicated in cell transformation and in the protection of genomic integrity and, therefore, proposed as a novel potential therapeutic target for cancer. In the absence of a crystal structure, we developed a three-dimensional model f...

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Identifiers

PMID: 23326322
DOI: 10.1371/journal.pone.0052011
PMCID: PMC3543423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23326322-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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