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BRAF V600E and previously unidentified KRAS G12C mutations in odontogenic tumors may affect MAPK activation differently depending on tumor type.

Genes, chromosomes & cancer - 1 Aug 2022

Oh Kyu-Young, Kim Ji-Hoon, Cho Sung-Dae, Yoon Hye-Jung, Lee Jae-Il, Hong Seong-Doo

Abstract excerpt

Although several types of odontogenic tumors share the same mutations in MAPK pathway genes, their effects on MAPK activation remain unclarified. This study aimed to evaluate the associations between these mutations and ERK phosphorylation in ameloblastoma and mixed odontogenic tumors (MOTs) and to analyze the expression pattern of phosphorylated ERK (p-ERK) for determining the involvement of MAPK activation in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35353428
DOI: 10.1002/gcc.23040

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