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Article

An association of CYP2A6 genotype and smoking topography.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Apr 2007

Strasser Andrew A, Malaiyandi Viba, Hoffmann Ewa, Tyndale Rachel F, Lerman Caryn

Abstract excerpt

Nicotine is metabolized into biologically inactive cotinine primarily by the cytochrome P450 enzyme CYP2A6. CYP2A6 genetic variations have been phenotypically grouped as slow, intermediate, and normal metabolizers. Slow metabolizers smoke fewer cigarettes daily and weekly, and have lower carbon monoxide (CO) and plasma nicotine levels, suggesting a reduced smoking rate compared with normal metabolizers. CYP2A6...

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Identifiers

PMID: 17454707
DOI: 10.1080/14622200701239605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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