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Article

Sequence dependence of C-end rule peptides in binding and activation of neuropilin-1 receptor.

Journal of structural biology - 1 May 2013

Zanuy David, Kotla Rohith, Nussinov Ruth, Teesalu Tambet, Sugahara Kazuki N, Alemán Carlos, Haspel Nurit

Abstract excerpt

Neuropilin-1 (NRP-1) is a hub receptor that plays an essential role in angiogenesis and vascular permeability. It is over-expressed in the new blood vessels grown by tumor cells and is a target for anti-tumor treatments. Peptides that expose the consensus sequence R/K/XXR/K at the C-terminus (C-end rule or CendR peptides) bind to NRP-1 and are internalized into the cell. We used peptide phage display binding...

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Identifiers

PMID: 23462097
DOI: 10.1016/j.jsb.2013.02.006
PMCID: PMC6146283

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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