Article
Another brick in the wall. Validation of the σ1 receptor 3D model by computer-assisted design, synthesis, and activity of new σ1 ligands.
Molecular pharmaceutics - 5 Nov 2012
Laurini Erik, Marson Domenico, Dal Col Valentina, Fermeglia Maurizio, Mamolo Maria Grazia, Zampieri Daniele, Vio Luciano, Pricl Sabrina
Abstract excerpt
Originally considered an enigmatic polypeptide, the σ(1) receptor has recently been identified as a unique ligand-regulated protein. Many studies have shown the potential of σ(1) receptor ligands for the treatment of various diseases of the central nervous system (CNS); nevertheless, almost no information about the 3D structure of the receptor and/or the possible modes of interaction of the σ(1) protein with its...
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