Article
New Crystal Form of Human Neuropilin-1 b1 Fragment with Six Electrostatic Mutations Complexed with KDKPPR Peptide Ligand.
Molecules (Basel, Switzerland) - 24 Jul 2023
Goudiaby Ibrahima, Malliavin Thérèse E, Mocchetti Eva, Mathiot Sandrine, Acherar Samir, Frochot Céline, Barberi-Heyob Muriel, Guillot Benoît, Favier Frédérique, Didierjean Claude, Jelsch Christian
Abstract excerpt
Neuropilin 1 (NRP1), a cell-surface co-receptor of a number of growth factors and other signaling molecules, has long been the focus of attention due to its association with the development and the progression of several types of cancer. For example, the KDKPPR peptide has recently been combined with a photosensitizer and a contrast agent to bind NRP1 for the detection and treatment by photodynamic therapy of...
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